Kandidosis granulomatosa adalah lesi granuloma yang disebabkan mukokutan kronik dan merupakan manifestasi kutan penyakit granulomatosis kronik. Penyakit ini termasuk kelompok penyakit kelainan genetik yang ditandai dengan hilangnya kemampuan fagosit yang berperan dalam infeksi bakteri atau jamur, misalnya kandida dan berbentuk granulomatosa. Bila awitan dini, akan terjadi disfungsi limfosit T, hilangnya respons imun selular terhadap antigen kandida, dan kegagalan respons hipersensitivitas tipe lambat.
Makalah ini melaporkan sebuah kasus yang jarang dijumpai dan penatalaksanaannya. Seorang perempuan usia 20 tahun, sejak usia 5 tahun timbul bintil-bintil merah di lengan kanan, membesar, bertambah banyak dan menyebar. Klinis tampak granuloma di hampir seluruh tubuh. Pada pemeriksaan laboratorium ditemukan hipereosinofilia dan neutropenia, jumlah CD4 tes Mantoux negatif dan limfosit T menurun. Pemeriksaan KOH ditemukan hifa dan ragi. Secara histopatologis tampak hifa dan spora jamur dalam jaringan granulasi, yang menyokong kandidosis granulomatosa. Diberikan terapi metotreksat, metilprednisolon dan itrakonazol serta terapi suportif. Setelah 3 bulan terapi terdapat perbaikan klinis, tetapi terjadi rekurensi setelah pasien putus obat 1 bulan. Disimpulkan adanya disfungsi imunitas dan ketidakpatuhan pasien yang menyebabkan rekurensi.
Kata kunci : kandidosis granulomatosa, kandidosis mukokutan kronik, itrakonazol.

    Granulomatosus candidosis is a granuloma lesion caused by chronic mucocutaneous candidiasis and is a cutaneous manifestation of chronic granulomatous disease. The disease is a genetic disorder characterized with the inability of phagositosis function in bacterial infection and mycosis, e.g candida. Early onset will lead to dysfunction of T-lymphocytes, absence of cell-mediated immunity to candidal antigens and failure of the delayed hypersensitivity. A rare case and the management is reported. A 20 year-old female complained that since she was 5 years old, papules appeared on her right arm, which enlarged in size and spread throughout her body. Clinically there were granulomas on almost all of her body. Laboratory findings were hipereosinophilia and neutropenia, and T-lymphocytes were decreased CD4 mantoux test was negative. KOH examination showed hypha and yeast. Histophologicaly examination showed hypha and spores in granulation tissue, which supported candida granuloma. The patient was treated with methotrexate, metilprednisolone, systemic itraconazole and supportif therapy. Three months after treatment the diasese improved clinically but recurrence occurred 1 month after the drug was stopped. It was cocluded that immunity dysfunction and poor  compliance lead to recurrency.
Key words: granulomatosa candidosis, chronic mucocutaneous candidosis, itraconazole