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Musinosis Papular (MP) atau liken miksedematosa merupakan penyakit yang jarang ditemukan, ditandai oleh erupsi papular likenoid, deposit musin, dan paraproteinemia. Musinosis Papular merupakan salah satu musinosis kutan idiopatik. Etiologi dan patogenesisnya sampai sekarang belum diketahui. Penyakit ini sering dihubungkan dengan paraproteinemia. Terdapat beberapa klasifikasi MP, yaitu berdasarkan klinis menurut Montgomery dan Underwood (1953), berdasarkan pola distribusi menurut Rongioletti (1993), dan berdasarkan klinikopatologis menurut Rongioletti dan Rebora (2001).Sesuai gambaran klinikopatologis, MP terbagi menjadi popular dan sklerodermoid generalisasta (skelromiksedema), MP lokalisata dan MP atipik/intermediate. Diagnosis disusun berdasarkan gambaran klinis dan histopatologis. MP mempunyai perjalanan penyakit yang kronis progresif dan bisanya tidak memiliki kecenderungan untuk resolusi spontan. Terapi MP tidak memuaskan dan tidak terdapat penelitian terapi dengan kontrol. Terapi topikal tidak membantu. Prognosis buruk, terutama pada pasien dengan penyakit difus disertai keterlibatan organ dalam. (MDVI 2007;34/1:99-104)

Kata kunci: musinosis papular, manifestasi klinis, pola distribusi, gambaran klinikopatologis

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Papular mucinosis (PM) or lichen myxedematosus is a rare disease characterized by a papular-lichenoid eruption, mucin deposition, and paraproteinemia. PM is a member of idiopathic cutaneous mucinoses. The etiology and pathogenisis remains unknown, usually connected to paraproteinemia. There are several PM classification, which are classified based on clinical manifestations by Montgomery and Underwood (1953), on distribution pattern by Rongioletti (1993), and on clinicopathologic findings by Rongioletti and Rebora (2001). According to clincopathologic pictures, PM consists of generalized papular and sclerodermoid MP, localized MP and typical/intermediate MP. Diagnosis is based on clinical pictures and histopathological findings. The nature of these disease is chronic progressive, without trend to spontaneous resolution. The treatment of PM remains unsatisfactory and controlled therapeutic trials are not available.Topical treatment cannot help. PM has bad prognosis, especially with diffuse type with internal organ involvement. (MDVI 2007’34/2:99-104)

Keywords: papular mucinosis, clinical manifestations, distribution patterns, clinicopathologic pictures.