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            Telah dilakukan penelitian pada 96 MSM (men who have sex with men) untuk mendeteksi uretritis non spesifik yang disebabkan oleh C. trachomasis (CT) dan N. gonorrhoeaea (NG) di klinik Perkumpulan Keluarga Berencana Indonesia (PKBI) Jakarta Timur. Untuk mengetahui proporsi uretritis nonspesifik digunakan pemeriksaan urin dengan leucocyte esterase test (LET), sedangkan proporsi C. trachomatis dan N. gonoorhoeae dengan Polymerase chain reaction (PCT).

            Subyek penelitian terbanyak berusia 26-30 tahun (50%), 52 orang (54,2%) dengan frekuensi hubungan seksual dalam 1 minggu < 5 orang, multi cara hubungan seksual pada 96 orang (100%) tetapi 49 orang (51%) kadang-kadang saja menggunakan kondom. Enampuluh tujuh orang (69,8%) mengkonsumsi NAPZA dan alkohol,  dan 34 orang dengan riwayat IMS, dengan gejala duh tubuh uretra.

            Proporsi kepositivan uretritis dengan LET dijumpai pada 15,6%, sedangkan dengan pemeriksaan PCR, CT dijumpai pada 13,5% dan NG pada 10,4% kasus. CT (+) dan LET (+) pada 26,6%, NG (+) dan LET (+) pada 46,6%.

            Dapat disimpulkan bahwa kepositivan PCR CT dan NG dengan LET (+) lebih kuat maknanya pada pemeriksaan LET dengan PCR NG, sehingga LET lebih dapat dipakai pada MSM yang bekerja sebagai penjaja seks untuk menduga adanya infeksi NG. Frekuensi hubungan seksual > 11 kali seminggu dan tidak pernah menggunakan kondom memiliki hubungan bermakna dengan infeksi CT dan MG.

Kata kunci: Uretritis, Chlamydia trachomatis, Neisseria gonorrhoeae, leukocyte esterase test, polymerase chain reaction.

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A study was done in 96 MSM (men who have sex with men) to determine proportion of urethritis due to Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) at Perkumpulan Keluarga Berencana Indonesia (PKBI) Clinic, Jakarta Timur. Urine test of Leucocyte esterase test (LET) was used to study the proportion of urethritis, and Polymerase chain reaction (PCR) for CT and NG infection.

Number of study population (SP) mostly in the age of 26-34 years (50%), number of sexual activity in one week < 5 times 52 person (54.2%), various manner in sexual activity 96 person (100%), occasionally used condom 49 person (51%). Characteristic in sexual activity in anogenital and orogenital insertif 96 person (100%), Number of NAPZA (Alcohol) user 67 person (69.8%), history of IMS patience that discharge from uretra 34 person (35.4%).

 Positive proportion urethritis with LET 15.6%, CT with PCR 13.5%, NG with PCR 10.4%, CT (+) on LET (+) 26.6%, and NG (+) on LET (+) 46.6%.

Findings from PCR CT and NG positive on LET positive prove that LET can be use for MSM who work as a sexual-related profession. The same between positive PCR CT and NG on LET positive means in relation of analyze LET with PCR NG. The use of LET is more adequate to detect NG infection. There were significant correlation among characteristic of sexual activity practice  in one week > 11 times, and never use condom.

Keywords: Urethritis, Chlamydia trachomatis, Neisseria gonorrhoeae, leukocyte esterase test, polymerase chain reaction.