ARTIKEL ASLI
HUBUNGAN KADAR CD4+ DENGAN INFEKSI JAMUR SUPERFISIALIS PADA PASIEN HIV DI RSUP H. ADAM MALIK MEDAN
Lukmanul Hakim Nasution, Sri Yusfinah Masfah Hanum, Sudarsono, Meidina Kusuma Wardani
Departemen Ilmu Kesehatan Kulit dan Kelamin FK Universitas Sumatera Utara/RSUP H. Adam Malik - Medan
ABSTRAK
Limfosit T CD4+ merupakan target utama HIV karena afinitas virus tersebut terhadap petanda molekul CD4+. Limfosit T CD4+ berperan pada beberapa fungsi imunologik penting dan hilangnya fungsi limfosit tersebut menyebabkan penurunan respons imun secara progresif. Sistem imun pejamu merupakan faktor penting bagi terjadinya infeksi jamur, termasuk infeksi jamur superfisialis. Mengetahui hubungan kadar CD4+ dengan infeksi jamur superfisialis pada pasien HIV/AIDS di RSUP H. Adam Malik Medan. Terhadap pasien yang memenuhi kriteria penelitian dilakukan anamnesis dan pemeriksaan dermatologis, selanjutnya dilakukan pemeriksaan kadar CD4+ dan pemeriksaan KOH atau pewarnaan gram serta kultur jamur dari lesi kulit. Untuk melihat proporsi dan karakteristik pasien disajikan dalam bentuk tabel dan dianalisis.Untuk melihat hubungan kadar limfosit T CD4+ dengan infeksi jamur superfisialis digunakan uji Chi-Square dengan kemaknaan p < 0,05. Proporsi infeksi jamur superfisialis sebesar 50,7%. Secara klinis, kandidiasis oral 41,1%, dan dermatofitosis 16,4% dengan rincian tinea korporis 4,1%, dan tinea kruris, tinea fasialis, onikomikosis masing-masing 2,7%; sedangkan tinea pedis, tinea manus, tinea kapitis masing-masing 1,4%. Penyebab terbanyak adalah spesies Candida terutama Candida albicans. Analisis statistik hubungan antara kadar limfosit T CD4+ dengan infeksi jamur superfisialis menunjukkan hasil p < 0,05. Ada hubungan antara kadar CD4+ dengan kejadian infeksi jamur superfisialis pada pasien HIV/AIDS. (MDVI 2011: 38/1; 6-10) Kata kunci : Infeksi jamur superfisialis, pasien HIV, kadar limfosit T CD4 +.
ABSTRACT
CD4+ T-lymphocytes are the prime target for HIV infection because the virus affinity against the marker molecule of CD4+. CD4+ T-lymphocytes play a role in several important immunologic functions and loss of function causes a progressive decline in immune responsse. Host immune system is an important factor for the occurrence of fungal infections including superficial fungal infections. To determine the correlation between CD4+ level and superficial fungal infections in people with HIV/AIDS in H. Adam Malik General Hospital Medan. To the patients who meet the criteria of the study, anamnesis and dermatological examination, further examination of CD4+ levels and KOH examination and culture or Gram staining of preparations from patients with skin lesions were conducted. To see the proportions and characteristics of the patients, data is presented in tabular form and then analized. To see the correlation between CD4+ levels and superficial fungal infections, Chi-Square test was used with significance at p < 0.05. The proportion of superficial fungal infection are 50.7%. Clinically, oral candidiasis 41.1%, and dermatophytosis 16,4% with the details tinea corporis 4.1%, and tinea cruris, tinea faciei, onychomycosis 2.7% respectively, whereas tinea pedis, tinea manuum, and tinea capitis 1.4% respectively. The most common cause is a species of Candida, especially Candida albicans. Statistical analysis of the correlation between CD4+ levels with superficial fungal infection showed p < 0.05. There is a correlation between CD4+ levels with the incidence of superficial fungal infections in people with HIV / AIDS. (MDVI 2011: 38/1; 6-10) Keyword : superficial fungal infection, HIV patient, CD4+ level

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