Plasma kaya trombosit (PKT) adalah fraksi plasma darah dengan konsentrasi trombosit 3-5 kali di atas nilai normal (konsentrasi trombosit pada whole blood). Trombosit mengandung lebih dari 30 protein bioaktif, berupa faktor pertumbuhan, berbagai sitokin, dan kemokin yang berperan penting pada proses penyembuhan luka, respons akut jaringan terhadap trauma, serta terlibat pada beberapa proses fisiologis selular, misalnya pertumbuhan, diferensiasi, dan replikasi sel. Sifat PKT yang autolog membuatnya relatif aman dan tidak berisiko menimbulkan reaksi alergik atau menularkan penyakit. Tingginya konsentrasi trombosit dan berbagai faktor pertumbuhan di dalamnya, telah membuat PKT dimanfaatkan pada banyak cabang ilmu kedokteran, termasuk dermatologi. Pada bidang dermatologi, PKT telah lama dimanfaatkan untuk penyembuhan luka kulit dan jaringan lunak. Penggunaan PKT di bidang bedah kulit dan dermatologi kosmetik juga berkembang pesat. Pada makalah ini dibahas penggunaan PKT pada ulkus kronis, ulkus diabetikum, luka traumatik akut, luka bakar, peremajaan kulit, kerontokan rambut, dan augmentasi jaringan (MDVI 2011; 38/1:22-28)

Kata kunci: Plasma kaya trombosit,

     Platelet-rich plasma (PRP) is a portion of the plasma fraction of blood containing a platelet concentration 3-5 times above baseline (whole blood platelet concentration). Platelet has more than 30 bioactive proteins, such as growth factors, cytokines, and chemokines that play an important role in the process of wound healing, traumatic acute response of the tissue, and in several physiological process, such as cellular growth, differentiation, and replication. The autologous nature of PRP has made it relatively safe and is not associated with any risk of allergic reaction nor disease transmission. The potential benefit of this high concentration of platelet and growth factors in PRP has led to an interest in its use in many fields of medicine, including dermatology. In dermatology, PRP has long been applied in the healing process of various skin and soft tissue injury. There has been also a dramatic increase in the use of PRP in the field of dermatosurgery and cosmetic dermatology.This article highlights the use of PRP in chronic ulcer, diabetic ulcer, acute traumatic injury, burns, skin rejuvenation, hair loss, and soft tissue augmentation. (MDVI 2011; 38/1:22:28 )

Key words: platelet-rich plasma, platelet, growth factors, wound healing